A Mycobacterium leprae Hsp65 mutant as a candidate for mitigating lupus aggravation in mice.
Hsp60 is an abundant and highly conserved family of intracellular molecules.Increased levels of this family of proteins have been observed in the extracellular compartment in chronic inflammation.Administration of M.leprae Hsp65 [WT] in [NZBxNZW]F(1) mice accelerates the Systemic Lupus Erythematosus [SLE] progression whereas the point mutated K(409